Faustinella et al. (1991) presented the case of two homozygous brothers in rs328 with another mutation Asp156Gly in LPL. They confirmed in vitro that the carboxyl terminus of LPL was not responsible for hyperlipoproteinemia type I. The minor allele frequencies of rs132642 and rs328 are 5.8% and 9.25% in dbSNP (1KGP Global group). All other five high-risk variants identified in Costa Ricans are presented as heterozygous, and only two have ClinVar annotations with uncertain or conflicting interpretations (CD36, GCKR, and GPD1). Here, GPD1 is linked to familial chylomicronemia syndrome.