Marginally weak genes (REEP6, HLA-A, TGFBR1, POLDIP2, MMP9, and VTN) are confirmed as leading edge genes within the AMD-related gene sets, including “GOBP: activation of the immune response,” “GOCC: photoreceptor inner segment,” “HP: choroidal neovasularization,” “HP: macular degeneration” among others. Here, HLA-A is linked to age-related macular degeneration.