All nine canonical pathways enriched by both gene lists had been reported in the AMD literature, including the complement system (Anderson et al., 2010; Ishikawa et al., 2016; Potilinski et al., 2021), the antigen presentation (Ambati et al., 2013; Potilinski et al., 2021), the LXR/RXR activation (Mukwaya et al., 2018; Choudhary et al., 2020) and the FXR/RXR activation (Kurji et al., 2010) pathways. This evidence concerns the gene NR1H4 and age-related macular degeneration.