In this sense, a wide distribution of tau was reported in all wasteosomes of both AD and non-AD patients (Singhrao et al., 1993) but in this study, dated in 1993, the authors used mouse anti-tau monoclonal antisera and a non-isotype specific anti-mouse IgG secondary antibody, which indicates that the staining is generated, at least in part, by the presence of IgMs. This evidence concerns the gene MAPT and Alzheimer disease.