This is the case, for example, for the frontotemporal lobar degenerations (FTLD), that includes among others the FTLD-TDP, with the presence and aggregation of p-TDP-43 protein, and the FTLD-FUS with the fused in sarcoma (FUS) protein accumulation (Uemura et al., 2023). The gene discussed is TARDBP; the disease is frontotemporal dementia.