Thus, we double-stained the hippocampal sections from AD and non-AD patients with the anti-p62 and the Tau5 antibodies after boiling the samples for different time periods (0, 10, 20, 30 and 40 min) with the intention of observing, at some intermediate times, both p62 and tau staining in the wasteosomes. The gene discussed is MAPT; the disease is Alzheimer disease.