Juopperi et al. (2012) reported that autophagy is dysfunctional in the astrocytes generated from iPSCs of an adult-onset patient with 50 CAG repeats and his daughter with juvenile HD (109 CAG repeats). iPSC-astrocytes of the juvenile HD patient showed even stronger upregulation in LC3B+ autophagic structures (immunostaining) which was confirmed by TEM as well (Juopperi et al., 2012). This evidence concerns the gene MAP1LC3B and Huntington disease.