Studies of LRRK2-G2019S mutant iPSC-derived dopaminergic neurons (DANs) revealed compromised autophagic maturation and clearance accompanied by morphological alterations of PD-DANs (Sánchez-Danés et al., 2012; Reinhardt et al., 2013; Su and Qi, 2013; Borgs et al., 2016). This evidence concerns the gene LRRK2 and Parkinson disease.