Moreover, studies demonstrated that in many cases iPSC-derived disease models don’t exhibit disease-associated phenotypes under normal culture condition (Dimos et al., 2008; Soldner et al., 2009; Zhang et al., 2010; HD iPSC Consortium, 2012) only upon introducing interventions to mimic aging-like phenotype (ROS, telomere manipulation, progerin, etc.)(HD iPSC Consortium, 2012; Miller et al., 2013; Vera et al., 2016; Wu et al., 2019; Chao et al., 2021). Here, LMNA is linked to Huntington disease.