Moreover, a kymograph from fruit fly motor neurons expressing TDP-43 A315T or M337V mutants showed RNA transport granules travel retrogradely, causing the cytoplasmic accumulation of TDP-43 which are reminiscent of ALS histology (Neumann et al., 2006; Alami et al., 2014). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.