At the molecular level, DJ-1 binds and inhibits the tumor suppressor phosphatase and tensin homolog (PTEN) [18], which is a negative regulator of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway involved in cancer cell survival, proliferation, and migration [14]. The gene discussed is AKT1; the disease is cancer.