In the setting of hyperinsulinemia activation of growth-promoting factors such as IGF-1 and M6P/IGF2R (tumor suppressor gene), IRS1 causes cellular proliferation, and in inflammatory cascade inflammatory milieus like free fatty acids, pro-inflammatory cytokines, ROS, JNK1, and decreased adiponectin, an anti-inflammatory polypeptide can cause further development of HCC [15-17]. This evidence concerns the gene IGF1 and hepatocellular carcinoma.