The TF was found to be upregulated in diseases such as multiple strokes and middle cerebral artery occlusion (MCAO) [8]. Recent animal studies have suggested that upregulation of SOX9 could promote ischemic brain injury (IBI) mainly through upregulating FOXO3 which itself is an important regulator of various cellular mechanisms including apoptosis, and autophagy metabolism [9]. Currently very limited studies have studied SOX9 association with AD, however, interestingly a recent study has shown that miR-22-3p can have a protective effect in AD by acting on SOX9 in the HC [10]. Here, FOXO3 is linked to Alzheimer disease.