FABP3 and acute coronary syndrome: H-FABP is considered an important diagnostic biomarker for acute coronary syndrome and acute kidney damage (63) and its release into the blood circulation occurs after myocardial damage (49), and this obtained result was confirmed histopathologically where the heart tissue from DM rats showed various alterations that included cardiomyocyte death, vacuolation, hyalinization, shrinkage, a reduction in cardiomyocytes, and interstitial mononuclear inflammatory cell infiltration, which are characteristics of DM cardiac dysfunction, as demonstrated by a number of prior investigations (58, 64).