CD8A and hepatocellular carcinoma: Nonetheless, it is noteworthy that the elimination of viruses by CD8 T cells is often accompanied by hepatic cell destruction, which not only directly results in liver impairment (Maini et al., 2000) but also induces liver fibrosis due to aberrant hepatic cell regeneration and repair of the liver, culminating in the ultimate progression to cirrhosis and hepatocellular carcinoma (Nakamoto et al., 1998; Sitia et al., 2012).