Moreover, kinases found to be upregulated by the infection of HIBCPP cells with both N. meningitidis strains in this analysis (downregulated in control cells) include MAPKAPK2, RPS6KB1, RET as well as AKT1 and AKT2, whereas PRKACA activity was upregulated only by MC58siaD. The gene discussed is MAPKAPK2; the disease is infection.