The other study addresses the possible underlying mechanism of TLR3-sensing of EBERs: EBER1 binds the cellular lupus erythematosus-associated antigen (La) to evade degradation, and this interaction induces the active secretion of EBER1-La complexes with the possibility of being secreted as an exosome during EBV infection (Figure 1). This evidence concerns the gene SSB and Epstein-Barr virus infection.