To evaluate the diagnostic and predictive value of serum SIRT1 expression combined with uterine artery hemodynamics, we performed unsupervised PCA analysis, supervised PLS-DA analysis, and cluster heatmap analysis and found that serum SIRT1 expression combined with uterine artery hemodynamics can effectively distinguish the disease severity and complicated fetal growth restriction in patients with preeclampsia. Here, SIRT1 is linked to preeclampsia.