One of this receptor is AGER1, also known as OCT48, which lowers AGEs and facilitates its clearance into urine (Vlassara et al., 2009b; Uribarri et al., 2011) and is known as an anti-inflammatory AGE receptor (Lu et al., 2004); it is downregulated in many autoimmune diseases such as CDK and diabetes (Stinghen et al., 2016). Here, DDOST is linked to diabetes mellitus.