To further confirm the effect of DON on the BLM-induced mice, five genes in the core of the PPI network, Col1a1 (encoding collagen type I alpha 1 chain), Timp1 (encoding TIMP metallopeptidase inhibitor 1), Ccl2 (encoding C-C motif chemokine ligand 2), Serpinb2 (encoding serpin family B member 2), and Tbx21 (encoding T-box transcription Factor 21) were quantitatively analyzed in lung tissue. The gene discussed is TBX21; the disease is Bloom syndrome.