Furthermore, the relative levels of pJAK2 and pSTAT3 increased to 2.04-fold and 2.88-fold, respectively, in the BLM-induced mice compared with those in the control group; while they were substantially reduced after DON treatment (all P < 0.05, Figure 5G-I), suggesting the vital function of the JAK2-STAT3 pathway in the protective effect of DON. This evidence concerns the gene JAK2 and Bloom syndrome.