The kidney-protective effects of EZH2 inhibition have been demonstrated in several investigations recently, inhibition of EZH2 was shown to reduce oxalate-induced kidney injury by modulating the JNK/FoxO3a pathway 43, and inhibition of EZH2 prevents cisplatin-induced renal tubular apoptosis and AKI by restoring E-calmodulin expression 44. Here, MAPK8 is linked to acute kidney injury.