However, increasing evidence suggests that activation of the Wnt/β-catenin pathway has a kidney-protective effect in the early pathological process of AKI, and β-catenin plays a key role in reducing the apoptosis of renal tubular epithelial cells in the acute phase of AKI, and study have demonstrated that Sox9 can continuously activate the wnt/β-catenin pathway to protect the IR-AKI 26, 51-53.In addition, the Wnt/β-catenin pathway is closely related to the inflammatory response 53. This evidence concerns the gene SOX9 and acute kidney injury.