DOCK7 is a RAC-GEF with the potential to regulate F-actin organization (Fig. 5A), consistent with previous publications reporting DOCK7-mediated RAC1/CDC42 - PAK1 activation in the DNA replication stress response 122, and the promotion of glioblastoma cell invasion by DOCK7 via RAC activation 123. Here, ARHGEF2 is linked to glioblastoma.