Consistently, the results of the second rotarod test showed that after 7 days of MPTP treatment, Calhm2 KO mice showed significant enhancement in locomotor performance compared to Calhm2 WT mice (Figure 1B-C), suggesting that knockout of Calhm2 was beneficial for MPTP treatment-induced PD symptoms in mice. The gene discussed is CALHM2; the disease is Parkinson disease.