EGR1 and neoplasm: It was then decomposed by H+ and GSH in the tumor and further released Zn2+ and Mn2+ to initiate subsequent combination therapy: DNAzyme-1 catalyzed the self-breaking of ultra-long DNA strands with Zn2+ as a cofactor, producing fragments containing DNAzyme-2; DNAzyme-2 catalyzed the lysis of mRNA with Mn2+ as a cofactor, resulting in the down-regulation of early growth reaction protein 1 (EGR-1), thereby inhibiting the proliferation of tumor cells and promoting their apoptosis.