PRL3 overexpression perturbs many cellular functions that are deregulated in cancers, leading to phenotypes such as increased cell proliferation, migration, invasion, metastasis, cell cycle deregulation, evasion of apoptosis, genomic instability, angiogenesis, deregulation of cellular metabolism, phenotypic plasticity, as well as alterations in the tumor microenvironment that are permissive for tumor growth and metastasis (Figure 1). This evidence concerns the gene PTP4A3 and cancer.