As previously described, PRL3 is also involved in inhibiting the transcription of endolysosomal genes to promote stemness; this further suggests PRL3 plays a significant role in regulating the endolysosomal system - a hub for multiple biological processes that are perturbed in cancer, such as autophagy, apoptosis, cell adhesion and migration 117. This evidence concerns the gene PTP4A3 and cancer.