Since then, several papers have further demonstrated that PRL3 promotes proliferation and tumorigenicity in vitro and in vivo in various cancer cell models, including mouse melanoma cells 41, 42, Chinese Hamster Ovary (CHO) cells, and human cancer cell lines including liver 14, ovarian 20, 43-45, gastric 46, 47, lung 24, 48, colon 49-53, breast 54, prostate 31, 55, esophageal 22, multiple myeloma (MM) 56, 57, glioma 58, classical Hodgkin lymphoma 34, Acute Myeloid Leukemia (AML) 59-61, Chronic Myeloid Leukemia (CML) 62, and T cell acute lymphoblastic leukemia (T-ALL) 63. This evidence concerns the gene PTP4A3 and melanoma.