PTP4A3 and cancer: PRL3 mini-body (lacking Fc domain) showed no therapeutic effect, suggesting PRL3-zumab recruits immune cells such as B cells, natural killer (NK) cells, and macrophages in an Fc receptor (FcR)-dependent manner, which implies the involvement of antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) in the elimination of cancer cells 8.