In this section, we highlight how PRL3 is a central node of many oncogenic pathways 118 that are often deregulated in many cancer types, including but not limited to transmembrane growth factor signaling (eg. ErbB), focal adhesion/integrin signaling, cytokine signaling, as well as pathways downstream of p53 and Wnt 71, 86(Figure 1). This evidence concerns the gene TP53 and cancer.