Pathway analysis of genes displaying co-expression further indicates that epithelial remodeling in EoE is associated with senescence, glucocorticoid signaling, and granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling while epithelial remodeling in ESCC is associated with cell proliferation and cell metabolism pathways. The gene discussed is CSF2; the disease is esophageal squamous cell carcinoma.