Furthermore, genes associated with granulocyte macrophage colony-stimulating factor (GM-CSF) were found in EoE-enriched clusters (Figure 6B; Table 1), consistent with GM-CSF signaling playing an active role in EoE epithelial remodeling in mice (38) as well as in eosinophil survival and epithelial crosstalk in EoE patients (39). Here, CSF2 is linked to eosinophilic esophagitis.