Given that angiogenesis is a complex biologic process in atherosclerosis 99, Liu and colleagues constructed a C-type atrial natriuretic factor (CANF)-conjugated nanoprobe, i.e. DOTA-CANF-comb nanoprobe, to detect natriuretic peptide clearance receptor (NPR-C) levels with PET in an animal model with atherosclerosis-like lesions 100. This evidence concerns the gene NPR3 and atherosclerosis.