The effect of icv CRF on 5-HT release appears to be specific to brain regions known to innervate the CeA, such as the dRN and mRN, but may also affect other brain regions such as BNST, PFC, or lateral habenula which also innervate the dRN, mRN, or CeA and are also involved regulating stress and anxiety (Challis et al., 2014; Ohmura et al., 2014; Dolzani et al., 2016; Marcinkiewcz et al., 2016). The gene discussed is CRH; the disease is Anxiety.