Galectin-3 is a ß-galactoside binding lectin that can drive neutrophil chemotaxis, bind TLR4, and increase production of pro-inflammatory cytokines during viral infections (Joo et al., 2001; Filer et al., 2009; Henderson and Sethi, 2009; Burguillos et al., 2015). Here, TLR4 is linked to viral infectious disease.