As for anti-LGI1 encephalitis, increased metabolism in the hippocampus, basal ganglia, and medial temporal lobe has been reported to be associated with hypometabolism within cortical areas, such as the parietal, frontal, and occipital lobes, the cingulate cortex, and the paracentral lobule (12, 15, 17, 19). The gene discussed is LGI1; the disease is viral encephalitis.