TMEM158 and pachyonychia congenita: What’s more, overexpression of TMEM158 is significantly associated with clinicopathologic features (including tumor size, TNM staging, and vascular infiltration) and poor prognosis of pancreatic cancer (PC) patients, and it could promote proliferation, migration, and invasion of PC cells through activation of transforming growth factor (TGF)-β1 and Phosphoinositide 3-Kinase (PI3K)/protein kinase B (AKT) signaling pathways (37).