Previous studies reported that MMP25-AS1/hsa-miR-10a-5p/SERPINE1 axis is a new prognostic biomarker related to the infiltration of immune cells in KIRC (44), tumor antigen, and immune subtype, guiding the development of mRNA vaccine for clearing renal cell carcinoma (45). The gene discussed is SERPINE1; the disease is renal cell carcinoma.