CEACAM5 and neoplasm: After all factors listed in Table 1 were brought into the logistic regression model as independent variables, we found that the cycle number of consolidation chemotherapy ≥1 (P=0.042), serum CEA before treatment <5ng/mL (P=0.005) and EMVI negative (P=0.045) were independent predictors of pCR and were significantly associated with higher pCR rate in LARC patients after nCRT (Table 2), and the longitudinal length of the tumor was not found to have independent predictive value, although this factor was found to have significant correlation with pCR in univariate analysis.