DAMPs and recognition receptors secreted extracellularly are required for the expression of ICD activity, promote DC maturation and nuclear factor-κB (NF-κB) activation through IFN-regulatory factors as well as MAPK and Akt pathways, facilitate migration and proliferation in local lymph nodes, enhance tumor antigen uptake and presentation, and produce IFN-γ, perforin-1, and granzyme B to trigger a direct cytotoxic response to kill residual tumor cells. The gene discussed is GZMB; the disease is neoplasm.