Some chemical drugs, radiotherapy, photodynamic therapy, lysing virus, and other therapies act on tumor cells, causing endoplasmic reticulum (ER) stress and the production of reactive oxygen species (ROS), as well as releasing immune signaling molecules from the cell, increasing tumor immunogenicity and enhancing the recognition and presentation ability of dendritic cells (DCs), activating tumor-specific cytotoxic T cells (cytotoxic T cells), and stimulating the release of IL-2, IL This mechanism results in apoptosis, which is known as ICD in cancers (20). The gene discussed is IL2; the disease is cancer.