Recently, a large number of molecular markers related to the onset and prognosis of AML, such as fusion genes CBFB–MYH11, RUNX1–RUNX1T1, and BCR-ABL1 caused by chromosome aberrations and mutant genes NPM1, TP53, and ASXL1, have been gradually discovered and investigated. The gene discussed is CBFB; the disease is acute myeloid leukemia.