A multivariate Cox regression analysis was performed on the 74 genes to obtain an AML prognostic risk score model composed of 8 genes: Risk score = CD58(–0.2484) + CLIC3 × 0.3613 – CUX1 × 0.7672 + ECE1 × 0.1624 + ETS2 × 0.4580 + SFXN3 × 0.2551 + SLC25A12 × 0.6498 + SQLE × 0.1993. The gene discussed is CLIC3; the disease is acute myeloid leukemia.