The mRNA expressions of the HIF-3a4 gene, the SOCS3 gene, and the p53 gene were significantly increased by infection with Ad-CD44-N-HIF3α4 (Figure 6A), Ad-SOCS3 (Figure 6B), and Ad-p53 (Figure 6C), respectively (p < 0.01). The gene discussed is TP53; the disease is infection.