Under culture conditions of hypoxia, Ad-CD44-N-HIF3α4 significantly decreased the mRNA expression of VEGF compared to the other adenoviral vectors or no infection (p < 0.05; Figure 7C), and the mRNA expression of B-cell lymphoma-extra arge (Bcl-xL) was significantly decreased in the cells infected with Ad-CD44-N-HIF-3α4 compared to cells infected with Ad-SOCS3 (p < 0.05; Figure 7D), while these changes were not observed under culture conditions of normoxia (Figures 7C, D). This evidence concerns the gene CD44 and infection.