Nurse-like cells (NLC) represent a population of leukemia-associated macrophages expressing CD14, CD45, HLA-DR, CD33, and CD68, which are induced by CLL cells through nicotinamide phosphoribosyl transferase (NAMPT) and high-mobility group protein B1 (HMGB1) signaling (41–43). This evidence concerns the gene HMGB1 and B-cell chronic lymphocytic leukemia.