Expressing high levels of complement receptors CR1 and CR2, these cells crosstalk with CLL cells via NF-κB independent interactions such as plexin-B1/CD100 and ICAM1/LFA-1 (intracellular adhesion molecule 1/lymphocyte function-associated antigen 1) (50, 51). This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.