The significantly upregulated proteins RAB14 (Ras-related protein Rab-14) and HCFC1 (Host cell factor 1) in IDC and ILC with the ER- and PR-positive, HER2-negative patients (cancer No. 415 and NATs No. 112) were analyzed from mRNA level based on the TCGA database. The gene discussed is HCFC1; the disease is cancer.