Immunosuppressive cells including Tregs, MDSCs and TAMs, up regulate immune checkpoint mediators like programmed death‐1 receptor (PD‐1)–ligand (PD‐L1) and CTL‐associated antigen 4 (CTLA‐4), conferring an inhibitory effect on T cells and NK cells which contribute to form a unique immune suppression tumor microenvironment of pancreatic cancer (10) (Table 1). Here, CTLA4 is linked to familial pancreatic carcinoma.