CXCL12 and pancreatic neoplasm: Pancreatic cancer cells secret of various cytokines (such as IL-10, TGF-B and IL-23) and chemokines (such as CXCL1-3, CXCL5, CXCL12, CCI2 and VEGF) to enhance the activation of stromal cells and the accumulation of immunosuppressive cells (8).