Pancreatic cancer with higher Treg and lower Th17 cells alter cytokine IL-10, IL-17, IL-23, INF-γ and TGF-β expression by regulating transcription factors such as CTLA-4, RORγt, ROR-α, and FoxP3 (48). This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.