SLCO2B1 and neoplasm: As shown in Figures 3A, B, OATP2B1 knockdown significantly reduced the ability of tumor xenografts to take up and retain MHI-148 by up to 43% when compared with control group at 4h after the tail vein injection (The average radient efficiency respectively is 1.27 ± 0.3×109 and 2.9 ± 0.4×109 [p/s/cm2/sr]/[μW/cm2]).