ABCG2 and hepatocellular carcinoma: Collectively, our data demonstrate that transporters of OATP2B1 and ABCG2, which regulated by β-catenin signaling pathway, mediate tumor-specific retention of MHI-148, and the inhibition of β-catenin signal pathway enhances the accumulation of MHI-148 in HCC tissues, which improves the efficacy of tumor imaging with MHI-148 in vivo (Figure 7E).