COL3A1 and Ehlers-Danlos syndrome, vascular type: The certainty diagnosis of vEDS is determined either by identification of a heterozygous pathogenic variant in COL3A1 on molecular genetic testing, by abnormalities in synthesis and mobility of type III collagen chains on biochemical analysis of type III procollagen from cultured fibroblasts, or even by histopathological examination of tissue biopsy; the latter one may be challenging, since histopathological findings of vEDS are not widely recognized (12).