To elucidate the potential mechanism of ALDH2's effect on the LPS-induced AKI, the lipid peroxidation end-product 4-HNE, a key ALDH2 substrate, and ROS, a major oxidative stress marker, were evaluated in ALDH2 KO and Alda-1 pretreatment mice, respectively. The gene discussed is ALDH2; the disease is acute kidney injury.