MRTFA and cardiac hypertrophy: Liu et al. found that MRTF-A in macrophages collaborates with transcription factor Sp1 and histone H3K9 demethylase KDM3A to promote integrin β2 (ITGB2) transcription, leading to an increase in the adhesion of macrophages to endothelial cells, eventually enhancing inflammatory response and cardiac hypertrophy following cardiac injury.