Other interestingly upregulated genes include BCL3, an anti-inflammatory NFKB inhibitor (31); KIF12, a microtubule motor associated with reduced lip toxicity (56); the interleukin-6 receptor, mutations of which have been associated with CAVD;(32, 33) and NQO1, an oxidoreductase associated with decreased calcification (34). Here, IL6R is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.