Irisin has multiple roles in the organism, among which it promotes cardiac progenitor cell-induced myocardial repair after the injury (70), affects blood pressure and controls hypertension through modulating vasodilatation as well as enhances endothelial barrier function (71) and prevents microvascular leakage thus improving pulmonary function, decreasing lung oedema and injury, and suppressing inflammation (72). This evidence concerns the gene FNDC5 and Hypertension.