TP53 and heart failure: Further studies have shown that wild-type p53 gene can promote the release of cytochrome C and other apoptosis inducing factors by affecting cell cycle and the change of mitochondrial Bcl-2/Bax ratio, start Caspase protease-cascaded reaction and activate the occurrence of myocardial cell apoptosis, so as to promote the apoptosis of cardiovascular system, and play an omportant role in the pathogenesis of myocardial infarction, heart failure, atherosclerosis and other cardiovascular diseases (128).