IFNG and inflammatory bowel disease: The functions of CD8+T cells in IBD were reported controversial, with some reports indicating anti-colitogenic properties and others showing their contribution to tissue inflammation, which could be explained by the diversity of sources and subtypes (78).The best known CD8+ T cells, also called cytotoxic T lymphocytes (CTL), are characterized by robust production of IFN-γ and cytolytic activities (79).