The results displayed a positive correlation between the CRFCS and the level of some anti-tumor immune cell infiltration, such as activated CD4 T cells (p<0.0001), activated dendritic cells (p =0.0142), central memory CD4 T cells (p<0.0001), central memory CD8 T cells (p =0.0025), and effector memory CD4 T cell (p<0.0001). Here, CD4 is linked to neoplasm.