Moreover, cNK cells also expressed more exhaustion markers than the NK cells from other groups, markedly upregulation of TIGIT, KLRC1 (NKG2), HAVCR2 (Tim-3), and downregulation of CD226 (DNAM-1), FCGR3A (CD16), and NCR3 (NKp30), which would limit the antitumor and anti-infection potential of NK cells in PSC patients. The gene discussed is CD226; the disease is infection.