PLAT and myasthenia gravis: To determine whether IFNβ failed to provide a protective effect in MG-specific IFNAR1 knockdown MCAO mice with delayed tPA treatment was due to the abrogated effect of IFNβ on modulating MG phenotypes, Ifnar1fl/fl-Cx3cr1CreERT2/+ and Cx3cr1CreERT2/+ mice were subjected to 40min MCAO followed by tPA or tPA+IFNβ treatment at 4.5h post-reperfusion and the ischemic brains were then harvested to assess the expression of inflammatory and anti-inflammatory molecules in MG.