However, we did not find any significant correlation between the proportion of CD57+KLRG1+ cells in CD8+ T cells with age in HC (Spearman’s r=0.1891, P=0.17, Figure 9A) or IBM cases (Spearman’s r=0.006, P=0.96, Figure 9B) Additionally, chronic antigenic stimulation has been found to result in T cell acquisition of a late-stage cellular differentiation phenotype featuring CD57 and KLRG1 upregulation (35, 51). Here, KLRG1 is linked to inclusion body myositis.