DCs chemotaxis-associated proteins CCL19, CCL20, and CCL21 were differentially elevated in the peripheral blood of patients with stage IIIB-C and IV colorectal cancer (one-way ANOVA, CCL19 control vs stage IV, p < 0.0001; CCL20 control vs stage IV, p = 0.0259; CCL21 control vs stage IIIB-C, p = 0.0078, control vs stage IV, p < 0.0001), suggesting a significant recruitment of DCs, especially mature DCs, in the advanced stage of colorectal cancer (Figure 4A). The gene discussed is CCL21; the disease is colorectal cancer.