Disruption of the intestinal barrier at the colorectal tumor site induces activation of innate immune cells and increased expression of pro-inflammatory cytokines such as tumor necrosis factor (TNF), one of the earliest and most important pro-inflammatory cytokines that activates other pro-inflammatory cytokines through the nuclear factor kappa-B (NF-κB) signaling pathway (14). This evidence concerns the gene TNF and colorectal neoplasm.