M1 macrophages exhibit enhanced antigen-presenting activity while secreting CXCR3 ligands (CXCL9, CXCL10, CXCL11) and CXCL16 to recruit Th1 and NK cells and secrete TNF-α, synergistically exerting anti-tumor functions. The gene discussed is CXCL16; the disease is neoplasm.