CCL27 and colorectal cancer: In addition, we detected upregulation of CCL25 and CCL27 in the peripheral blood of patients with stage IV colorectal cancer (one-way ANOVA, CCL25 control vs stage IV, p = 0.0100; CCL27 control vs stage IV, p = 0.0015), which were associated with the recruitment of type II intrinsic lymphocytes (ILC2s) and regulatory T cells in vivo, respectively (Figures 5E, F).