In this comprehensive investigation of circulating cytokines and colorectal cancer, our main observation was that 17 markers involved in several components of the inflammatory process, CCL7, CCL8, CCL15, CCL2, MIF, IL-1β, CXCL2, CXCL5, CXCL6, IL-8, CCL19, CCL21, CXCL9, CXCL10, CCL11, CCL26, and IL-2, were significantly upregulated in the peripheral blood of patients with advanced colorectal cancer. This evidence concerns the gene CXCL5 and colorectal cancer.