TF and thrombophilia: A variety of cytokines secreted from mononuclear, endothelial, and leukemic cells, including IL-1β, TNF-α, IL-8, and IL-6, promote hypercoagulability by upregulating the expression of procoagulant factors such as TF and adhesive molecules (AM) and downregulation of fibrinolytic factors such as thrombomodulin (TM) (38, 62, 63).