The expression levels of cytokines in newly diagnosed APL patients with ED were IL-1β 5.56 (2.19-6.61) pg/ml, IL-5 10.40 (3.19-15.7) pg/ml, IL-6 69.31 (12.24-84.37) pg/ml, IL-8 65.96 (11.42-290.65) pg/ml, IL-10 29.26 (4.35-55.26) pg/ml, IL-12p70 5.24 (3.93-7.98) pg/ml, IL-17A 12.76 (9.94-14.55) pg/ml, IL-17F 9.26 (3.70-13.76) pg/ml, IL-22 2.12 (1.49-3.79) pg/ml, and TNF-β 11.66 (8.84-15.46) pg/ml. This evidence concerns the gene IL1B and acute promyelocytic leukemia.