A variety of cytokines secreted from mononuclear, endothelial, and leukemic cells, including IL-1β, TNF-α, IL-8, and IL-6, promote hypercoagulability by upregulating the expression of procoagulant factors such as TF and adhesive molecules (AM) and downregulation of fibrinolytic factors such as thrombomodulin (TM) (38, 62, 63). The gene discussed is THBD; the disease is thrombophilia.