PLAU and cancer: In addition, DIC is a complex process characterized by the initiation of coagulation and fibrinolytic activation, involving elevated levels of multiple procoagulant substances and plasminogen activators, such as tissue factor (TF), cancer procoagulant (CP), urokinase-type plasminogen activator (u-PA), and tissue-type plasminogen activator (t-PA), amongst others (54–58), resulting in the prolongation of PT and APTT and reducing the platelet counts.