In another study, FGR kinase was found to be a key regulator of pro-inflammatory adipose tissue macrophage activation, diet-induced OB, insulin resistance, and hepatic steatosis, knockdown of FGR reduced lipid accumulation and lipogenic gene expression, and low expression of FGR prevented macrophage polarization while preventing high-fat diet-induced OB in mice (66). This evidence concerns the gene FGR and fatty liver disease.