The age group (P=0.011), BMI group (P=0.033), renal insufficiency (P<0.001), atrial thrombosis (P=0.012), NYHA class (P<0.001), etiological diagnosis of valves (P=0.002), surgical approaches (P<0.001), maze procedure (P<0.001), operative time (P<0.001), CPB time (P<0.001), aortic cross-clamp (ACC) time (P<0.001), and CRP group (P<0.001) were identified as significant risk factors for postoperative BNP level >400 pg/ml. This evidence concerns the gene CRP and Renal insufficiency.